Pharmacodynamics Introduction

Pharmacodynamics is the study of biological measurements that represent the effects of a drug on the body. Pharmacodynamic measurements are hugely varied and new pharmacodynamic endpoints are constantly invented. Some example pharmacodynamic measurements include

• Protein phosphorylation status of a drug target
• Transcription of genes influenced by the drug
• Downstream physiological responses such as blood pressure
• Assessments of response to stimulus such as a reaction time or an induced immune response
• Patient reports of symptom severity on continuous or categorical scales
• Counts of patient events such as seizures
• Durations until critical events like relapse or hospitalization

The list is potentially endless and encompasses many different types of data with complex relationships to drug effects and disease progression.

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